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Immunoregulation، جلد ۱، شماره ۲، صفحات ۱۰۱-۱۰۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Effect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor |
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| چکیده انگلیسی مقاله |
Background: Hydatid cyst is the larval stage of the tape worm parasite, Echinococcus granulosus. Human is infected by ingestion of parasite ova excreted in dog feces. The anticancer activity of different antigens of hydatid cyst has been reported in the previous works. In this research, the role of immune system in induction of this anticancer activity has been investigated.Materials and Methods: Spleen cells of mice immunized with hydatid cyst antigens were transferred to the recipient mice that had already been challenged with melanoma cells. Also, mice with melanoma cancer were injected with antisera raised against hydatid cyst antigens. In all above mice, tumor growth was measured using a caliper. Results: Passive transfer of spleen cells resulted in significant inhibition of melanoma cancer growth. However passive transfer of antisera did not affect cancer growth in the recipient mice.Conclusion: According to the results of this work, cellular immunity but not humoral immunity may be involved in induction of anticancer activities of hydatid cyst. |
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| کلیدواژههای انگلیسی مقاله |
Hydatid cyst, Cellular immunity, Humoral immunity, Melanoma |
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| نویسندگان مقاله |
Hossein Yousofi Darani |
Cancer Prevention Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Fereshteh Jafaei Nodeh |
Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Seyedeh Tala Ramazaninia |
Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Seyedeh Maryam Sharafi |
Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
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| نشانی اینترنتی |
http://immunoreg.shahed.ac.ir/article_730_503759a0c84170a21376184c016692b1.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2435/article-2435-1033845.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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