سامانه اطلاعات پژوهشی ایران - NRIP Journals

سه شنبه 18 شهریور 1404


Research in Molecular Medicine، جلد ۳، شماره ۴، صفحات ۳۵-۴۰


عنوان فارسی

چکیده فارسی مقاله

کلیدواژه‌های فارسی مقاله

عنوان انگلیسی	Salivary VEGF-R3, TNF-α, TGF-β and IL-17A/F Levels in Patients with Minor Aphthous

چکیده انگلیسی مقاله	Background : Recurrent aphthous stomatitis (RAS) is one of the most common mucosal ulcerative of oral cavity. Role of immune system, especially cytokines in immunopathogenesis of aphthous stomatitis was not highly considered. The aim of this study was to evaluate the levels of salivary cytokines, including VEGF-R3, TGF-&beta1, TNF-&alpha, and IL-17A/F in patients with RAS in two clinical stages, ulcerative and healing period. Material and Methods: In this case –control study, 18 patients with RAS (case group) and 18 healthy individuals (control groups) who were matched for age and sex, were selected. In both ulcerative and healing stages, unstimulated saliva of patients with RAS and healthy controls were collected. Levels of salivary cytokines, including VEGF-R3, TGF-&beta, TNF-&alpha, and IL-17A/F at each stage was determined by ELISA procedure and result were compared with the control group. Results: The levels of salivary VEGF-R3 in the ulcerative (5.92 1.87ng/ml) and healing (7.14 ±3.1 ng/ml) stages significantly decreased comparing with control group ( 9.71±2.24 ng/ml). Moreover, the level of salivary TGF-&beta1 in ulcerative (142.21±18.7 pg/ml) and healing (167.02±28.1 pg/ml) stages significantly reduced comparing with control group (178.35±55.67 pg/ml). In addition, our finding showed that both inflammatory cytokines including TNF-&alpha and IL-17 A/F significantly increased comparing to control group. The level of salivary TNF-&alpha in ulcerative (34.9±11.35pg/ml) and healing (28.09±9.07pg/ml) stages significantly increased comparing with control group (10.76±1.83 pg/ml). Also, the IL-17 A/F level in the ulcerative (96.44±25.74 pg/ml) and healing (79.17±24.96 pg/ml) stages significantly increased comparing to the control group (53.47±13 pg/ml). Conclusion: Our finding in this study showed that the reduction of VEGF-R3 and TGF-&beta1 cytokines and increasing of inflammatory cytokines such as TNF-&alpha and IL-17 A/F are effective in the pathogenesis of minor aphthous particularly in ulcerative stage. .

کلیدواژه‌های انگلیسی مقاله	IL-17A/F, Minor Aphthous, TGF-β1, TNFα, Saliva, VEGF-R3.

نویسندگان مقاله	صفورا سیفی \| safoura seifi babol university of medical sciences سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences) قربان ملیجی \| ghorban maliji babol university of medical sciences سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences) مینا مطلب نژاد \| mina motallebnejad babol university of medical sciences سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences) احسان ملیجی \| ehsan maliji babol university of medical sciences سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences) محمود خسروی سامانی \| mahmood khosravi samani babol university of medical sciences سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences) رامین فرخی \| ramin farokhi babol university of medical sciences سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences) حسام بابایی \| hesam babaei babol university of medical sciences سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

نشانی اینترنتی	http://rmm.mazums.ac.ir/browse.php?a_code=A-10-790-1&slc_lang=en&sid=en
فایل مقاله	فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده	en
موضوعات مقاله منتشر شده	دندانپزشکی
نوع مقاله منتشر شده	پژوهشی

برگشت به: صفحه اول پایگاه \| نسخه مرتبط \| نشریه مرتبط \| فهرست نشریات