| چکیده انگلیسی مقاله |
Background: We aimed here to investigate the association between alleles and genotypes of APOE and Age-related macular degeneration (AMD) development. Materials and Methods: After ophthalmological examination, 120 patients with confirmed AMD and 120 healthy controls were enrolled in the study. The polymorphic segment of APOE gene was PCR-amplified and sequenced to determine the frequency distribution of polymorphic alleles and genotypes of this gene in the sample population. Results: The frequency distribution of APOE alleles and genotypes differed significantly between the patients and the control groups (P< 0.05). The frequency of APOE&epsilon2 in patients was higher than controls (P = 0.00) and this variant allele showed a significant association with AMD even after removal of the effects of age, sex and smoking by logestic regression analysis (P = 0.00, OR= 3.439 CI 95% 1.664-7.108). On the other hand, the frequency distribution of APOE&epsilon4 was not statistically different between patients and healthy controls. Conclusion: The results show a moderate positive association between APOE &epsilon2 and AMD, but current data does not show any role for APOE &epsilon4 in protection from AMD. However, more studies are required to reveal the possible role of APOE in the pathogenesis of AMD. |
| نویسندگان مقاله |
محمد عسکری | mohammad askari
cellular and molecular research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
امین رضا نیک پور | amin reza nikpoor
department of immunology, faculty of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
هاجر آرین | hajar aryan
fazeli-sanati genetic laboratory, tehran, iran
حمید قایدی | hamid ghaedi
department of medical genetics, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
جواد اختری | javad akhtari
immunogenetics research center, faculty of medicine, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
اسعد آذرنژاد | asaad azarnejad
department of medical biotechnology, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
کاظم موسوی زاده | kazem mousavizadeh
tehran 1445613122, iran
محمد حسین صنعتی | mohammad hossein sanati
national institute for genetic engineering and biotechnology, tehran, iran
علیرضا ایرانی | alireza irani
eye resarch center, rassoul akram hospital, tehran university of medical sceince, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
خلیل قاسمی فلاورجانی | khalil ghasemi falavarjani
eye resarch center, rassoul akram hospital, tehran university of medical sceince, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
حسین نظری | hossein nazari
eye resarch center, rassoul akram hospital, tehran university of medical sceince, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
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