سامانه اطلاعات پژوهشی ایران - NRIP Journals

چهارشنبه 19 شهریور 1404


Research in Molecular Medicine، جلد ۲، شماره ۴، صفحات ۱۸-۲۳


عنوان فارسی

چکیده فارسی مقاله

کلیدواژه‌های فارسی مقاله

عنوان انگلیسی	The potential of human-derived periodontal ligament stem cells to osteogenic differentiation: An In vitro investigation

چکیده انگلیسی مقاله	Background: Periodontal ligament stem cells (PDLSCs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. Materials and Methods: This study examined the effects of dexamethasone (Dex) on human PDLSCs in vitro. PDLSCs obtained from the roots of patient’s teeth were cultured with Dex (0.01 μM), and their proliferation was measured. The osteogenic differentiation was assessed by alkaline phosphatase (ALP) activity and Alizarin Red-S staining for calcium deposition. Results: After the administration of 0.01 μM Dex, the activity of ALP increased significantly. Furthermore, mineralized nodule formation showing the intracellular calcium deposition was significantly higher in the Dex-treated cells than that of the control cells. Conclusion: Collectively, Dex has positive effects on osteogenic differentiation of human PDLSCs in vitro. It is suggested that PDLSCs may serve as a potential material for periodontal tissue regeneration.

کلیدواژه‌های انگلیسی مقاله

نویسندگان مقاله	بهزاد هوشمند \| behzad houshmand department of periodontics, school of dentistry, shahid beheshti university of medical sciences, tehran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences) ام البنین امجدی \| omolbanin amjadi molecular and cell biology research center, department of immunology, school of medicine, mazandaran university of medical sciences, mazandaran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences) علیرضا رفیعی \| alireza rafiei molecular and cell biology research center, department of immunology, school of medicine, mazandaran university of medical sciences, mazandaran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences) محمدعلی روزگار \| mohammadali rouzegar department of periodontology, school of dentistery, ilam university of medical sciences, ilam, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences) محمدرضا ابریشمی \| mohammadreza abrishami department of periodontics, school of dentistry, shahid beheshti university of medical sciences, tehran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences) محمدرضا طالبی اردکانی \| mohammadreza talebi ardakani department of periodontics, school of dentistry, shahid beheshti university of medical sciences, tehran, iran سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی	http://rmm.mazums.ac.ir/browse.php?a_code=A-10-25-7&slc_lang=en&sid=en
فایل مقاله	فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده	en
موضوعات مقاله منتشر شده	ایمونولوژی
نوع مقاله منتشر شده	پژوهشی

برگشت به: صفحه اول پایگاه \| نسخه مرتبط \| نشریه مرتبط \| فهرست نشریات