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Research in Molecular Medicine، جلد ۲، شماره ۴، صفحات ۲۴-۲۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association between Epstein - Barr Virus (EBV) and Breast Cancer |
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| چکیده انگلیسی مقاله |
Background: Breast cancer is the most common malignancy in females worldwide. Several etiological factors including environmental factors have been recognized for breast cancer. Epstein Barr virus as a viral etiological factor has been proposed. So far, several studies have investigated the relationship between development of breast cancer and Epstein Barr virus, but few have been done in Iran. The aim of this study was to determine whether there was an association between EBV infection and female breast cancer in Iran. Materials and Methods: We analyzed paraffin embedded breast tissue specimens by polymerase chain reaction (PCR) including breast cancer specimens (as case group) and breast fibroadenoma specimens (as control group). PCR was performed to amplify specific sequences of EBV. Results: From 130 cases of breast samples, 67 cases of breast cancer tissues and 41 cases of breast fibroadenoma tissues had adequate quality and quantity of DNA to detect EBV. PCR for EBV was positive in 4 invasive ductal carcinoma specimens (7.3%) and only one of the fibroadenoma specimens (2.4%). No significant association was found between EBV infection and invasive ductal carcinoma (p> 0.05). Also, patient’s age and histological grade of IDC were not correlated with EBV infection (p>0.05). Conclusion: We observed no etiologic association between EBV infection and invasive ductal carcinoma of female breast in our regions however, further studies are required to elucidate this association . |
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| نویسندگان مقاله |
ژیلا ترابی زاده | zhila torabizadeh
department of pathology - - imam khomeini hospital mazandaran university of medical sciences razi st. sari, iran i
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
علیرضا ناجی | alireza nadji
virology research center - - masih daneshvari hospital, shahid beheshti university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
فرشاد نقش وار | farshad naghshvar
department of pathology - - imam khomeini hospital mazandaran university of medical sciences razi st. sari, iran i
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
آناهیتا نصرتی | anahita nosrati
department of pathology - - imam khomeini hospital mazandaran university of medical sciences razi st. sari, iran i
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
محسن پارسا | mohsen parsa
department of pathology - - imam khomeini hospital mazandaran university of medical sciences razi st. sari, iran i
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-615-9&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
آسیب شناسی |
| نوع مقاله منتشر شده |
پژوهشی |
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