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Research in Molecular Medicine، جلد ۲، شماره ۲، صفحات ۱-۱۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Inflammation, a Key Factor in Cancer Ambush |
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| چکیده انگلیسی مقاله |
Inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, UV radiation, stress and etc. Persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from T cells. These molecules (e.g. IL-6, TNF-&alpha, IL-1&beta and IL-17) are mostly pleiotropic cytokines involved in multiple signaling cascades. NF-&kappaB, STAT3, and HIF-1&alpha are the major engaged pathways directing to several downstream targets associating with tumorigenesis and inflammation. Carcinogenesis processes such as DNA mutation/damage, proliferation, angiogenesis, apoptosis, and invasion are implicated to inflammation. Clearly there is a closely association between cancer and inflammation reported as “Seven Hallmark of Cancer”. The elucidation of relationship between inflammation and cancer and their interaction may result in effective therapy and prevention. Gastric cancer is one of the main cancer involved in complex correlation of inflammation and cancer. Inflammation in gastric epithelium could trigger cellular transformation and promote invasion by inducing immune responses and utilizing signaling cascades. Gastric tumor microenvironment has inverse association by providing cytokines and inflammatory mediators. This closely relationship facilitates gastric tumor development and the induction of chronic inflammation in tumor microenvironment. The current review will focus on describing the possible and critical ways in which inflammation and cancer are linked together with specific view to gastric cancer and inflammation. Finally, it introduces some putative treatment generally used in this way in order to direct more attention for further exploration. |
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| نویسندگان مقاله |
ام البنین امجدی | omolbanin amjadi
km 17 khazarabad road, khazar sq, sari, iran
علیرضا رفیعی | alireza rafiei
km 17 khazarabad road, khazar sq, sari, iran
ابوالقاسم عجمی | abolghasem ajami
km 17 khazarabad road, khazar sq, sari, iran
وحید حسینی | vahid hosseini
inflammatory diseases of upper gi tract research center, department of internal medicine, faculty of medicine, mazandaran university of medical sciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
حسین عسگریان عمران | hossein asgarian omran
molecular and cell biology research center, department of immunology, faculty of medicine, mazandaran university of medicalsciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-615-2&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمونولوژی |
| نوع مقاله منتشر شده |
review |
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