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Research in Molecular Medicine، جلد ۱، شماره ۳، صفحات ۱-۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Roles of Chromatin insulators in gene regulation and diseases |
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| چکیده انگلیسی مقاله |
With advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. Long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of chromosomal structures. These elements are DNA-protein complexes which can mediate interactions within and between chromosomes. In doing so, they can bring close together regulatory sequences located at large distances from each other. In addition, insulators may be important in remodeling the architecture of chromosomes in the cell cycle. Here, we review recent data revealing the structure and properties of these DNA-protein complexes, their global role in regulation of transcription, and the mechanisms by which misregulation of their function leads to various human diseases such as cancers and autoimmune diseases. |
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| کلیدواژه‌های انگلیسی مقاله |
Insulator |
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| نویسندگان مقاله |
فرشید یگانه | farshid yeganeh
سید محمد جواد موسوی | seyed mohamad javad mousavi
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-26-12&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
review |
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