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Research in Molecular Medicine، جلد ۱، شماره ۳، صفحات ۲۸-۳۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Effect of Teucrium polium leaf extracts on AMPK level in Isolated Rat Pancreases |
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| چکیده انگلیسی مقاله |
Background: The purpose of this study is to evaluate effects of Teucrium polium (TP) leaf extracts on adenosine monophosphate activated protein kinase (AMPK) level in isolated pancreases. Materials and Methods: In this experimental study, two groups of rats were used as a control group, and diabetic group. In the end of experimental period the animals were sacrificed then pancreas were removed, then isolated rat pancreas was cultured in buffer with or without TP leaf extracts. Measuring the sample glucose level was carried out by spectrophotometric method ( Jenway ,Model 6505 ,UK, Pars Azmmon Co. ,Tehran, IRAN) . Insulin level was assayed by an enzyme immunoassay ELISA kit specific for rats made by Mercodia Rat insulin ELISA ( 10-1250-01,Mercodia AB, Uppsala, Sweden). The adenosine monophosphate activated protein kinase level was determined by ELISA assay method using a rat phosphorylated AMPK ELISA kit ( CSB-E11337r, Cusabio Biotech Co .,LTD). Results: The results indicate that addition of TP leaf extract significantly increased AMPK level and insulin content compared to untreated group (p< 0.05). Conclusion: These results support the potential of TP leaf extract as a therapeutic modality for diabetes. However, further studies will be necessary to confirm this potential. |
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| نویسندگان مقاله |
دردی قوجق | durdi qujeq
department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)
محسن تاتار | mohsen tatar
shiraz university
سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)
فریده فیضی | farideh feizi
هادی پارسیان | hadi parsian
سهراب حلال خور | sohrab halalkhor
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-609-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
شیمی دارویی |
| نوع مقاله منتشر شده |
پژوهشی |
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