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Research in Molecular Medicine، جلد ۱، شماره ۱، صفحات ۳۰-۳۵
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Prevalence of EPIYA motifs in Helicobacter pylori strains isolated from patients with gastroduodenal disorders in northern Iran |
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| چکیده انگلیسی مقاله |
Background: Cytotoxin-associated gene A (CagA)-positive strains of Helicobacter pylori are associated with gastroduodenal diseases. Evidences have suggested that the type of H pylori CagA EPIYA motifs may be associated with specific disorders (i.e., gastritis, peptic ulcer, or gastric cancer). We investigated the prevalence of different EPIYA motifs (A, B, C, or D) in H. pylori strains isolated from patients with recurrent dyspepsia who underwent upper gastrointestinal (GI) endoscopy. Materials and Methods: H. pylori strains were isolated from biopsy specimens of 220 patients with dyspepsia symptoms. The presence of glmM gene, as a housekeeping gene CagA and pattern of cagA EPIYA motifs were genotyped using by polymerase chain reaction (PCR) method.The association between the type of motifs and disease state determined by the Chi-square test, Fisher’s exact test, and logistic regression.Results: CagA-positive H. pylori were identified in 125(57%) of patients with gastrointestinal disorders, of whom 36(28.6%) were isolated from gastritis, 31 (24.6%) from duodenal ulcer, and 58 (46.4%) from gastric cancer. The frequency of pattern of cagA EPIYA motifs were 39 (31.2%) AB motifs, 54 (43.2%) ABC motifs, and 32 (25.6%) ABCC motifs and not detected D motifs. Gastric cancer risk was estimated to be 2.57 times higher in patients infected by strains with ABCC motif when compared with gastritis and duodenal ulcer patients (P=0.03). Moreover, patients with C- containing motifs were 2.27 times more likely to be affilicted with gastric cancer than duodenal ulcer. AB motif was more associated with gastritis and duodenal ulcer than ABC and ABCC motifs. Conclusion: The results suggested that cag-EPIYA ABCC might be associated with gastric cancer, while EPIYA-AB might be is associated with duodenal ulcer. |
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| نویسندگان مقاله |
ابوالقاسم عجمی | abolghasem ajami
molecular and cell biology cente , faculty of medicine, mazandaran university of medical sciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
مجتبی شادمان | mojtaba shadman
department of immunology, faculty of medicine, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
علیرضا رفیعی | alireza rafiei
molecular and cell biology research center, faculty of medicine, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
وحید حسینی | vahid hosseini
department of internal medicine, imam hospital, faculty of medicine, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
امین talebibezmin آبادی | amin talebibezmin abadi
molecular and cell biology research center, faculty of medicine, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
احد علیزاده | ahad alizadeh
department of biostatistics, faculty of health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
زهرا حسینی خواه | zahra hosseini khah
molecular and cell biology research center, faculty of medicine, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-587-1&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
گوارش و کبد |
| نوع مقاله منتشر شده |
پژوهشی |
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