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Research in Molecular Medicine، جلد ۱، شماره ۱، صفحات ۴۱-۴۳
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Alterations in salivary IgA levels in infectious and inflammatory disorders of upper respiratory tract |
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| چکیده انگلیسی مقاله |
Background: The airway surfaces are one of the most common ways of entry of infectious agents. Oral cavity associated lymphoid tissues are inductive site of humoral immune responses in inflammatory and infectious disorders of the upper respiratory tract. These lymphoid tissues play important roles in the induction of salivary IgA. The impact of upper respiratory tract diseases on salivary IgA production has not been fully understood. Therefore, in this study, we investigated the salivary IgA levels in patients suffered from upper respiratory tract diseases to indicate the effect of these diseases on salivary IgA production. Materials and Methods: In this study, salivary IgA level of 156 patients with inflammatory diseases of the upper respiratory tract including chronic rhinosinusitis, ear and pharynx diseases have been evaluated by direct immunoenzymatic determination. Results: In pharynx disorders 11.8 % of patients were IgA deficient , 76.2 % were normal and11.8 % had elevated level of IgA .In patients with chronic rhinosinusitis IgA deficiency was observed in 9.2 % , 75.9 % were normal and there was an elevation in 14.8 % of patients .In ear disorders 11.6% were IgA deficient ,76.7 % normal and 11.6 % had elevated IgA level. Conclusion: This study provided evidence for the first time that changes in salivary IgA level are almost the same in different sites of infectious and inflammatory diseases of upper respiratory tract. Our investigation revealed that local up regulation of salivary IgA is not particular interest in majority of patients with upper respiratory tract infections. |
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| نویسندگان مقاله |
عباس هاشمی | abbas hashemi
mazandaran university of medical sciences, sari .iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
سعید عابدیان کناری | saeid abediankenari
mazandaran universituy of medical sciences
عبدالله مدنی | abdollah madani
mazandaran universituy of medical sciences
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-186-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمونولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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