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Basic and Clinical Neuroscience، جلد ۱۰، شماره ۴، صفحات ۳۶۳-۳۷۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Introducing Genes With Significant Role in Migraine: An Interactomic Approach |
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| چکیده انگلیسی مقاله |
Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers. Methods: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened. Results: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes. Conclusion: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine. |
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| کلیدواژههای انگلیسی مقاله |
Migraine disorders, Protein interaction maps, Genes |
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| نویسندگان مقاله |
| Mona Zamanian-Azodi
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Mostafa Rezaei-Tavirani
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Reza Mahmoud Robati
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-941-5&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/198/article-198-1733031.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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