Research in Molecular Medicine، جلد ۷، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی The Effect of Dracocephalum kotschyi Alcoholic Extract on the BCL2 and BAX expression in SKBR3 Cell Line
چکیده انگلیسی مقاله Background: Breast cancer is the most prevalent malignancy among women in the worldwide and the outbreak in Iranian women is growing. Iranian patients with breast cancer are younger than their Western counterparts. Dracocephalum kotschyi is a wild-growing flowering plant belonging to the family Labiatae and found in Iran. This plant has been applied in Iran folk medicine. The aim of this study was to investigate the effect of Dracocephalum kotschyi alcoholic extract on cell proliferation and viability and also the expression level of BCL2 and BAX in breast cancer cell line. Materials and methods: In this experimental study, the SKBR3 cell line was chosen for treatment with the Dracocephalum kotschyi alcoholic extract. Cell proliferation and cell viability was evaluated in the presence of various concentrations of the Dracocephalum kotschyi alcoholic extract using MTT-method. Additionally, the impact of the Dracocephalum kotschyi alcoholic extract on the expression level of BCL2 and BAX was examined using quantitative real-time polymerase chain reaction (qRT-PCR). Results: The results indicated anticancer characteristics of the Dracocephalum kotschyi alcoholic extract on cell proliferation and cell viability. Moreover, Dracocephalum kotschyi alcoholic extract led to the decreased expression of BCL2 and increased expression of BAX. Conclusion: In overall, Dracocephalum kotschyi can be a proper choice for designing anticancer drugs as a potential candidate for major investigations on breast cancer.
کلیدواژه‌های انگلیسی مقاله BAX, BCL2, Breast cancer, Dracocephalum kotschyi.
نویسندگان مقاله | Fatemeh Ketabchi
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Faezeh Namazi
Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.


| Nasrin Hadi
Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Medical Genetics Research Center of Genome.


| Farinaz Khosravian
Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Medical Genetics Research Center of Genome.


| Mirza mohammad Raisinia
Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran


| Mansoor Salehi
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1119-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده پژوهشی
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