| چکیده انگلیسی مقاله |
Background: Parvovirus 4 (PARV4) was first discovered in 2005, in a hepatitis B virus–infected injecting drug user (IDU). To date, the best evidence about PARV4 transmission is parenteral roots and comes from IDU individuals. It seems that the prevalence of the virus in the normal population is very low. In this study, we investigated the prevalence of PARV4 virus among patients with chronic HCV infection compared with healthy controls and related risk factors among these groups. Materials and Methods: A total of 206 patients, including 103 patients with chronic HCV infection and 103 healthy controls, were studied by use of nested-PCR and also real-time PCR techniques. Results: AST enzyme levels with a mean of 40.45+34.84 and 18.58+5.9 in patients and healthy group respectively and the amount of enzyme ALT among patients with a mean of 40.45+35.75 and 21.50+11.35 in patients and healthy group respectively, were reported. Finally, after screening all DNA samples from patients and controls, we discovered that none of these people are infected with the PARV4 virus. Conclusion: This study is the first to investigate the occurrence of PARV4 among HCV patients in Iran. The results show that, the virus is not important in Iranian population, even in patients with blood born infections such as HCV and further studies in other areas and various groups are required. |
| نویسندگان مقاله |
حسنا رستگارپویانی | Hosna Rastegarpouyani
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، پژوهشکده بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
سید مسعود حسینی | Seyed Masoud Hosseini
PhD of Virology, Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran
دکترای ویروس شناسی، گروه میکروبیولوژی، دانشکده علوم زیستی، دانشگاه شهید بهشتی، تهران، ایران
سید رضا محبی | Seyed Reza Mohebbi
PhD of Virology, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
دکترای ویروس شناسی، مرکز تحقیقات بیماریهای گوارش و کبد، پژوهشکده بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
پدرام عظیم زاده | Pedram Azimzadeh
PhD Student in Cellular and Molecular Biology,Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences, Tehran, Iran
دانشجوی دکترای زیست شناسی سلولی و مولکولی، مرکز تحقیقات بیماریهای گوارش و کبد، پژوهشکده بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
شبنم کاظمیان | Shabnam Kazemian
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، پژوهشکده بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
مهسا سعیدی نیاسر | Mahsa Saeedi Niasar
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
مرکز تحقیقات بیماریهای گوارش و کبد، پژوهشکده بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
افسانه شریفیان | Afsaneh Sharifian
Specialist in Gastroenterology and Hepatology, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
فوق تخصص گوارش و کبد، مرکز تحقیقات بیماریهای گوارش و کبد، پژوهشکده بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
محمدرضا زالی | Mohammad Reza Zali
Specialist in Gastroenterology and Hepatology, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
فوق تخصص گوارش و کبد، مرکز تحقیقات بیماریهای گوارش و کبد، پژوهشکده بیماریهای گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
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