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، جلد ۱۲، شماره ۴، صفحات ۲۵-۳۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts |
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| چکیده انگلیسی مقاله |
We evaluated ameliorative effects of Jamun seed and orange peel extracts on liver toxicity in cypermethrin exposed rat. Methods: Rats were given following treatments daily for 30 d: Group A: Control Group B: Rats received cypermethrin Group C: These rats received cypermethrin and Jamun seed extract simultaneously Group D: These rats received cypermethrin and orange peel extract simultaneously Group E: Rats received orange peel extract Group F: Rats received Jamun seed extract In respective groups dose of cypermethrin, Jamun seed and orange peel extract were 25 mg/ kg body wt, 200 mg/kg body wt and 200 mg/kg body wt, respectively. Liver was fixed for light and electron microscopic studies. Results: After 15 d cypermethrin or cypermethrin+JSE or cypermethrin+OPE treatment hepatocytes exhibited increased cell size, nuclei became more hyperchromatic and hypertrophied. Degeneration of nuclei and dilatation of sinusoids have been noticed. After 30 d cypermethrin treatment hepatocytes exhibit more pronounced hypertrophy with hyperchromatic nuclei. Few hepatocytes exhibit nuclei with irregular boundaries. Hepatocytes show foamy cytoplasm and few vacuoles. Focal necrosis visible at certain places. Binucleated cells are also encountered. In cypermethrin+JSE and cypermethrin+OPE treated rats, hepatocytes exhibit hypertrophy, hyperchromatic nuclei and dilatation of sinusoids. Degeneration of hepatocytes are seen at some places, however, focal necrosis is not seen in these groups. No noticeable histological alterations are seen in orange peel extract (group E) and jamun seed extract (group F) treated rats. Conclusion: Cypermethrin induced hepatic toxicity can be protected by treatment with Jamun seed and orange peel extract. |
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| نویسندگان مقاله |
| Babita Deep Srivastava
Department of Zoology, DDU Gorakhpur University, Gorakhpur, India.
| Manish Srivastava
Department of Chemistry, Digvijai Nath P.G. College, Gorakhpur, India.
| Sunil Kumar Srivastav
Department of Zoology, DDU Gorakhpur University, Gorakhpur, India.
| Nobuo Suzuki
PhD of Environmental Toxicology, Institute of Nature and Environmental Technology, Kanazawa University, Ogi, Noto-cho, Ishikawa, Japan.
| Ajai Kumar Srivastav
Department of Zoology, DDU Gorakhpur University, Gorakhpur, India.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-74-7&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049534.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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