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، جلد ۱۲، شماره ۳، صفحات ۹-۱۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A Comparative Analysis of Saffron and Methylprednisolone on Bleomycin-Induced Pulmonary Fibrosis in Rats |
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| چکیده انگلیسی مقاله |
Background: The purpose of this study was to compare the effects of saffron and methylprednisolone on bleomycin-induced pulmonary fibrosis in rats. Methods: This study was conducted in Bushehr, southern Iran in 2017.The animals were divided into four groups of five rats each. Three groups were injected with a single intratracheal dose of bleomycin (5 mg/kg). The fourth group was administered with normal saline at the same volume (200 µl). Saffron extract dissolved in water was given to one group (100 mg /body weight) orally while intraperitoneal injection of methylprednisolone (2.5 mg/kg) injected to another one for 16 days. The rats were sacrificed 28 days following surgery and their right and left lungs were removed and washed for measuring lung indices, myeloperoxidase activities and finally histopathological examination. Results: Injection of bleomycin caused decrement of body weight aggravated by intraperitoneal methylprednisolone treatment. Lung indices were increased in the bleomycin-treated group compared with the control, while methylprednisolone, unlike saffron, had no preventive effects on it. Both saffron and methylprednisolone treatment prevented the increase in lung myeloperoxidase as a destructive enzyme. In addition, excessive collagen deposition and thickening of alveolar septa were significantly prevented with saffron treatment as compared to methylprednisolone injection following hematoxylin and eosin staining. Conclusion: Saffron with established antioxidant properties could prevent some detrimental effects in bleomycin-induced pulmonary fibrosis even more than methylprednisolone injection known as a standard therapy in this murine model. More investigations must be carried out to examine the beneficial or harmful effects of this remedy. |
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| کلیدواژه‌های انگلیسی مقاله |
Fibrosis, Lung, Methylprednisolone, Saffron |
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| نویسندگان مقاله |
| Mehrzad Bahtouee
Department of Internal Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
| Hossein Fatemikia
Departments of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
| Ali Movahed
PhD of Biochemistry, Persian Gulf Tropical Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
| Abdolhamid Esmaili
Department of Pathology, Bushehr University of Medical Sciences, Bushehr, Iran.
| Yaghoob Hassan
BSc of Nutrition, Student Research Committee Center, Bushehr University of Medical Sciences, Bushehr, Iran.
| Mohammad Zarei
Department of Internal Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
| Ramin Seyedian
Department of Pharmacology, Bushehr University of Medical Sciences, Bushehr, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-76-3&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049539.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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