| چکیده انگلیسی مقاله |
Background: Malaria is a worldwide threat, which affects millions of people. Although several antimalarial has been reported, they are either not effective or toxic. This study evaluated the antimalarial efficacy and safety of stem bark aqueous extracts of Khaya grandifoliola (KG) and Enantia chlorantha (EC) in Plasmodium berghie (NK65S) infected Swiss mice. Methods: Forty-two animals were grouped into six groups. Group A (control) comprised uninfected animals given sterile placebo. Group B was infected but untreated. Groups C, D, E, and F were infected and treated with 50 mg/kg artemisinin-based combination therapy (ACT), 400 mg/kg body weight of KG, EC, and the combined extracts (200 mg/ml body weight each) respectively. Results: Alkaloids, terpenoids, glycosides, phenolics, flavonoids, tannin and saponins were all present in the two extracts. The percentage parasitemia in the treated groups C, D, E, and F was significantly (P˂0.05) reduced from 44%, 24%, 35%, and 31% to 17%, 8%, 9% and 8% respectively. The level of creatinine C (1.33±0.08 g/d), D (2.07±0.15 g/d), E (2.17±0.24 g/d) and F (1.20±0.0.12 g/d) increased significantly (P˂0.05) compared to group A (0.73±0.08 g/d). There was no significant difference in the urea level, potassium and sodium concentrations among all the groups. Conclusion: The efficacy and renal safety of oral administration of aqueous stem bark extract of KG and EC were confirmed. Therefore, the extracts could be used as alternatives to standard drugs in the management of malaria. |
| نویسندگان مقاله |
| Ismaila Olanrewaju Nurain
Department of Biochemistry, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria.
| Clement Olatunbosun Bewaji
Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria.
| Abdulazeez Aderemi Abubakar
Department of Medical Laboratory Science, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria.
| Abdulrazaq Mustapha
Department of Biochemistry, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria.
| Emmanuel Oladipo Ajani
Department of Biochemistry, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria.
| Saeed Sabiu
Department of Biochemistry, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria.
| Lutfat Abimbola Usman
Department of Biochemistry, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria.
| Hassan Taye Abdulhameed
Department of Biochemistry, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria.
| Sikiru Bolaji Ahmed
Department of Biochemistry, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria.
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