، جلد ۱۱، شماره ۶، صفحات ۷-۱۲
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عنوان انگلیسی Saffron Protection against Bleomycin-Induced Pulmonary Fibrosis in Rats
چکیده انگلیسی مقاله Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human.  Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via intratracheal tube (n=6) in 2015. Sham group received normal saline. Saffron aqueous extract (50 mg/kg and 100 mg/kg) were given orally in two different treated groups with bleomycin for 28 days. Lung Indices was calculated at the end of this experiment. Lung segments fixed in 10% formaldehyde were used for pathological preparation with Hematoxylin & Eosin and trichrome staining. Results: The body weight was decreased and lung Indices increased in bleomycin group (P< 0.5). Bleomycin administration increased myeloperoxidase, malondialdehyde and finally TNF-α in lung tissue homogenates (P< 0.05) compared with sham group. The fibrotic process and thickening of alveolar septa in treated rats with bleomycin were increased by H&E and Masson Trichrome staining. Saffron treatment (50 and 100 mg/kg) attenuated the increase in MDA (264.43±10.4 nmol/g by the higher dose versus 378.4±18.1nmol/g), MPO (0.19±0.03 and 0.13± 0.04 IU/ml versus 0.39.2±0.05 IU/ml) and TNF-α level (18.42±3.7 ng/ml and14.31±3.6 ng /ml versus 35.32±4.2) in lung homogenates compared to bleomycin group (P< 0.05). It decreased collagen accumulation and alveolar destructive patterns in pulmonary fibrosis. Conclusion: This study introduces saffron as novel anti-fibrotic agent against bleomycin-induced fibrosis due to histological examinations and preventive effects on destructive enzyme release in rats.
کلیدواژه‌های انگلیسی مقاله Bleomycin, Fibrosis, Rat, Saffron
نویسندگان مقاله | Mehrzad Bahtouee
Department of Internal Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.


| Hossein Fatemikia
Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran.


| Khalil Pourkhalili
Department of Physiology, Bushehr University of Medical Sciences, Bushehr, Iran.


| Euikyung Kim
Department of Toxicology, College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea.


| Hamid Reza Rahimi
Department of Pathology, Bushehr University of Medical Sciences, Bushehr, Iran.


| Zahra Tavosi
Department of Internal Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.


| Abdol hamid Esmaili
Department of Pathology, Bushehr University of Medical Sciences, Bushehr, Iran.


| Abdollah Hajivandi
Department of Biostatistics, Bushehr University of Medical Sciences, Bushehr,Iran.


| Yaghoob Hassan
MSc of Nutrition, Research Center, Bushehr University of Medical Science, Bushehr, Iran.


| Ramin Seyedian
Department of Pharmacology, Bushehr University of Medical Sciences, Bushehr, Iran.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-76-2&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049563.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده عمومی
نوع مقاله منتشر شده پژوهشی
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