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، جلد ۱۱، شماره ۳، صفحات ۱-۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Hydrocortisone Increases the Vinblastine-Induced Chromosomal Damages in L929 Cells Investigated by the Micronucleus Assay on Cytokinesis-Blocked Binucleated Cells |
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| چکیده انگلیسی مقاله |
Background: Stress may cause damages to DNA or/and change the ability of the cells to overcome these damages. It may also cause irregularities in the cell cycle and induce abnormal cell divisions through glucocorticoid-dependent functions. The abnormal cell divisions, in turn, lead to chromosomal mal-segregation and aneuploidy. In this study, the effects of the stress hormone, hydrocortisone (HYD), were investigated on the induced chromosomal abnormalities by vinblastine (VIN) during cell cycle in L929 cells. Methods: This work was performed in winter 2013 at Department of Biology, University of Ferdowsi, Mashhad, Iran. Cultured cells were divided into different groups including control, VIN-treated, HYD treated and VIN+HYD co-treated cells. The induced chromosomal damages were investigated by micronucleus assay in cytokinesis-blocked binucleated cells. Results: Although HYD by itself did not increase the micronuclei (Mn) frequency, co-treatment of cells with VIN and HYD led to significant increase (P< 0.05) in the frequency of Mn in comparison to control and VIN treated groups. Conclusion: Cells treated with stress hormone are more sensitive to damages induced by VIN. Therefore, stress may not directly result in genetic instability, it can increase the harmful effects associated with other genotoxic agents. |
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| نویسندگان مقاله |
| Tahere Ebrahimipour
Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran.
| Farhang Haddad
Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran.
| Maryam Moghaddam Matin
Department of Biology and Institute of Biotechnology, Cell and Molecular Biotechnology Research Group, Ferdowsi University of Mashhad, Mashhad, Iran.
| Ali Moghimi
Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-439-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049586.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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