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، جلد ۱۱، شماره ۳، صفحات ۴۷-۵۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of Vitamin C on Paraoxonase1 Arylesterase Activity in Rats Exposed to Arsenic |
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| چکیده انگلیسی مقاله |
Background: Arsenic as an environmental toxicant is able to induced oxidative stress. The present study aimed to evaluate of vitamin C supplementation on the paraoxonase1 (PON1) arylesterase activity (responsible for hydrolysing lipid-peroxides) in rat exposed to arsenic. Methods: The study was conducted in the Faculty of Veterinary Medicine, Tabriz Islamic Azad University, Tabriz, Iran in 20015. Thirty-two adult male rats weighing 200-350 g were randomly divided into 4 groups: group I (Normal healthy rat), group II [treated with sodium arsenite (100 ppm in drinking water)], group III [treated with vitamin C supplementation (200 mg/kg via gavage)] group IV (treated with sodium arsenite and vitamin c 100 ppm and 200 mg/kg respectively). Results: Vitamin C supplementation increased paraoxonase1 (PON1) arylesterase activity (P< 0.05) but had no significant effect on serum levels of HDL, triglyceride and cholesterol. Conclusion: PON1 arylesterase activity is independent of changes in HDL and lipid profile, and vitamin C with different mechanisms such as radical scavenging activity and reduction of oxidative stress leads to increased activity of paraoxonase. |
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| کلیدواژه‌های انگلیسی مقاله |
Arsenic, Paraoxonase 1, Rat, Vitamin C |
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| نویسندگان مقاله |
| Felor Zargari
Department of Medical Science, Marand Branch, Islamic Azad University, Marand, Iran.
| Hamid Tabaghchi Saeedy
Department of Biology, Ahar Branch, Islamic Azad University, Ahar, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-405-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049593.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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