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، جلد ۱۱، شماره ۱، صفحات ۵۵-۵۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Administration of Root Ethanolic Extract of Aristolochia Ringens on the Liver Functional Indices of Male Wistar Rats |
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| چکیده انگلیسی مقاله |
Background: The alcoholic decoction of root ethanolic extract of Aristolochia ringens is taken orally to treat various ailments in South-west Nigeria without prior knowledge of its potential toxic effect. Therefore, this study aimed at assessing the toxicity potentials of root ethanolic extract of A. ringens on functional indices and histology of the liver. Methods: Twenty male rats were randomized into four groups of five animals each. Group A (control) received 0.5 ml of distilled water, group B, C and D received 75, 150 and 300 mg/kg b. wt. of the extract respectively. The administration was done orally and lasted for fourteen days. Results: The extract significantly reduced the activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT) as well as reduction in the level of serum albumin and direct bilirubin (P< 0.05) while the level of total bilirubin increased. The activities of these enzymes i.e. ALP, ALT and AST increased in the serum at all the doses investigated. Conclusion: Ethanolic extract from A. ringens root may not be completely safe when administered repeatedly. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Abdulhakeem Olarewaju Sulyman
Department of Biosciences and Biotechnology (Biochemistry Unit), Kwara State University, Malete, Ilorin, Nigeria.
| Jubril Olayinka Akolade
MSc of Biochemistry, Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex, Sheda, Abuja, Nigeria.
| Asiat Na’Allah
Department of Biological Sciences (Biochemistry Unit) Al-Hikmah University, Ilorin, Nigeria.
| Raliat Abimbola Aladodo
Department of Biosciences and Biotechnology (Biochemistry Unit), Kwara State University, Malete, Ilorin, Nigeria.
| Habeeb Olasunkanmi Jamiu
Department of Biosciences and Biotechnology (Biochemistry Unit), Kwara State University, Malete, Ilorin, Nigeria.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-393-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049609.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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