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، جلد ۱۰، شماره ۵، صفحات ۱۷-۲۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Helianthus annuus Leaf Ameliorates Postprandial Hyperglycaemia by Inhibiting Carbohydrate Hydrolyzing Enzymes Associated with Type-2 Diabetes |
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| چکیده انگلیسی مقاله |
Background: Diabetes mellitus is a chronic disease. Decreasing postprandial hyperglycemia by retarding glucose absorption through inhibiting carbohydrates digesting enzymes (α-amylase and α-glucosidase) is one of many approaches used for the management of this disease. This study was aimed at evaluating the normoglycaemic potential of Helianthus annuus leaf. Methods: The effect of the in vitro inhibitory of different extracts (acetone, ethyl acetate and hexane) of the plant was assessed on the activities of diabetes-related enzymes (α-amylase and α-glucosidase). Results: The hexane extract of H. annuus leaf displayed the best inhibitory activity against α-amylase and α-glucosidase as indicated by the IC50 values (3.92 ± 0.02 mg mL-1) and (3.29 ± 0.12 mg mL-1), respectively. Lineweaver-Burk plot of inhibition of α-amylase and α-glucosidase by this extract showed that it was competitive and non-competitive mode, respectively. Conclusion: H. annuus leaf possesses hypoglycaemic potential which may be due to the inhibition of pancreatic α-amylase and intestinal α-glucosidase. |
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| نویسندگان مقاله |
| Oluwafemi Adeleke Ojo
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria.
| Adebola Busola Ojo
Department of Biochemistry, Ekiti State University, Ado-Ekiti, Nigeria.
| Basiru Ajiboye
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria.
| Israel Olayide
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria.
| Adewale Fadaka
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-371-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049621.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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