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، جلد ۱۰، شماره ۱، صفحات ۳۱-۴۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Vitamin C and Chitosan Alleviate Toxic Effects of Paraquat on Some Biochemical Parameters in Hepatocytes of Common Carp |
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| چکیده انگلیسی مقاله |
Background: Paraquat is nonselective bipyridyl herbicide that induces hepatotoxicity through oxidative stress. Vitamin C and chitosan have antioxidant as well as radical scavenger properties and show protective effects against reactive oxygen species (ROS). In the present study, hepatoprotective effects of chitosan and vitamin C were evaluated in common carp exposed to paraquat. Methods: While exposed to 0.02 mg. L-1paraquat for 21 days, common carp were fed chitosan (1000 mg. kg‑1 feed), vitamin C (1000 mg. kg-1 feed), and vitamin C combined with chitosan. At the end of the experiment, activities of hepatic enzymes and oxidative stress biomarkers were evaluated. Results: Paraquat induces changes in the activity of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase and lactate dehydrogenase in liver tissue of fish. However, these enzymes were restored to normal levels in fish fed with vitamin C and vitamin C combined with chitosan following exposure to paraquat. Increased levels of malondialdehyde were observed in liver after exposure to paraquat, while glucose-6-phosphate dehydrogenase and catalase activities and the total antioxidant levels decreased. Administration of vitamin C combined with chitosan significantly reduced malondialdehyde levels and increased the total antioxidant capacity, glucose-6-phosphate dehydrogenase and catalase activities. Conclusion: Administration of vitamin C is effective in reducing liver toxicity of paraquat. However, administrating both vitamin C and chitosan is more effective. In other words, chitosan and vitamin C have a synergic effect. They could be used as hepatoprotective agents against paraquat-induced hepatotoxicity in fish. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
زینب شریفی نسب | Zeinab Sharifinasab
Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran.
مهدی بنایی | Mahdi Banaee
Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran.
محمد محیسنی | Mohammad Mohiseni
Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran.
احمد نوری | Ahmad Noori
Department of Aquaculture, Hormozgan University, Bandar Abbas, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-88-6&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049654.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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