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، جلد ۶، شماره ۱۹، صفحات ۷۴۶-۷۵۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Aluminium Phosphide Poisoning on Blood Cortisol Level |
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| چکیده انگلیسی مقاله |
Background: Acute intoxication with ALP is extremely lethal. The present study was conducted to determine the range of serum cortisol levels in ALP poisoning and its correlation with patient outcome. Methods: This study was carried out on patients who were intoxicated with ALP. Their demographic data and pertinent findings in their history and physical examination were recorded at the time of arrival and also when shock and severe metabolic acidosis emerged. 5cc blood was taken from the patients to measure blood cortisol level, when shock and severe metabolic acidosis developed. Blood cortisol level analysis was performed using ELISA method. Data analysis was done using SPSS software version 16.0. Results: The average ingested dose was 1.98+1.79 tablets each containing 3 grams of ALP. Overall, 77% of the patients presented tachycardia and hypotension. Blood cortisol level less than 15 µg/dl, 15-33 µg/dl, and more than 34 µg/dl were regarded as adrenal insufficiency, critical illness-related corticosteroid insufficiency, and adequate adrenal response, respectively. Eventually, 3 patients fell within the first category, 24 patients matched with the second category, and 3 patients corresponded to the last category. Conclusion: Blood cortisol concentration is satisfactory only in 10% of the patients. In majority of the patients although it is not apparently low, it has not shown the expected rise comparable to the shock and stress state of such patients. It defines a role for corticosteroids therapy in management of ALP poisoning, particularly if it does not respond to conventional treatments. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
فریبا فرنقی | Fariba Farnaghi
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
هاله طالایی | Haleh Talaie
Department of Infectious Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
زهرا پورنصیری | Zahra Pournasiri
Department of Pediatric Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
رکسانا صدقی | Roksana Sadeghi
Department of Cardiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
حمید اولیایی | Hamid Owliaey
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
حسین حسنیان مقدم | Hossein Hassanian-Moghaddam
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
شاهین شادنیا | Shahin Shadnia
Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-29-14&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049762.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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