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، جلد ۵، شماره ۱۵، صفحات ۵۵۸-۵۶۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
The Cytotoxic and Synergistic Effects of Flavonoid Derivatives on Doxorubicin Cytotoxicity in Hela, MDA-MB-231, and HT-29 Cancer Cells |
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| چکیده انگلیسی مقاله |
Background: Flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. Methods: The cytotoxic effects of three synthesized flavonoid derivatives (K3, K4 and K5) were evaluated against Hela , MDA-MB -231 and HT-29 cancer cells using MTT assay. Results: The results showed that these flavonoids were not cytotoxic at any tested concentrations (0.1, 0.05, 0.01, and 0.001 mM). To evaluate the possible synergistic effect of synthetic flavonoids with chemotherapeutic agent, the compound (K4) was examined against Hela and MDA-MB-231 cells in combination with different concentrations of doxorubicin (0.01 and 0.001mM). This combination treatment significantly increased the cytotoxicity of doxorubicin (P < 0.05). Conclusion: Synthesized flavonoids could be used either in combination therapy with other chemotherapeutic agents or used as antioxidants in food supplements. |
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| نویسندگان مقاله |
حجت صادقی علی آبادی | Hojjat Sadeghi-Aliabadi
School of Pharmacy and Pharmaceutical Sciences, Isfahan, Iran.
حسین موسوی | Hossein Mosavi
Isfahan University of Medical Sciences, Isfahan, Iran.
مینا میریان | Mina Mirian
Isfahan University of Medical Sciences, Isfahan, Iran.
سعید کاخکی | Saeed Kakhki
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
افشین زرقی | Afshin Zarghi
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-81&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049798.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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