|
|
، جلد ۲، شماره ۳، صفحات ۲۱۱-۲۱۵
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Pentoxifylline Attenuates Malathion-Induced Oxidative Damage in Rat |
|
| چکیده انگلیسی مقاله |
Introduction: Toxic effects of pesticides are commonly associated with reactive oxygen species damage and pentoxifylline a phosphodiesterase inhibitor is a drug well known for antioxidant properties. The purpose of this study was to evaluate the oxidative damages following a subacute exposure to malathion, an organophosphorus insecticide and pentoxifylline's ability to counteract these effects. Material and Methods: Malathion (200 mg/kg/day) and pentoxifylline (50 mg/kg/day) alone or in combination were administered intraperitoneally to rats and after one week, total antioxidant capacity (TAC) and total thiol groups (TTG) were measured in their blood. Results: Pentoxifylline increased total antioxidant capacity (TAC) and total thiol groups (TTG) in blood significantly compared to malathion which decreased them. Conclusion: Our findings suggest that oxidative stress occurs in exposure to malathion and oxidative damage may be a contributory factor in complications associated with malathion. The results indicate that malathion exposure decreases TAC and TTG, a process involved in oxidative stress and pentoxifylline could prevent this damage. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
اکرم رنجبر | Akram Ranjbar
Department of Toxicology, Hamedan University of Medical Sciences, H amedan, Iran
رضوان صالحی دوست | Rezvan Salehidoost
Shariati Hospital Tehran University of Medical sciences, Tehran. Iran
مریم بعیری | Maryam Baeeri
Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center
محمد عبدالهی | Mohammad Abdollahi
Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center
|
|
| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-45&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049844.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|