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، جلد ۲، شماره ۳، صفحات ۶۳-۶۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Fatal Pancytopenia Associated with Radium-223 Dichloride in a Patient with Castration-Resistant Prostate Cancer and Multiple Bone Metastases |
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| چکیده انگلیسی مقاله |
Radium-223 dichloride (Ra-223) is an alpha-emitting radioisotope that targets osteoblastic metastasis of prostate cancer. For Ra-223, a favorable safety profile has been described. However, here we report a case of a fatal hematologic toxicity following the administration of Ra-223 observed at our hospital. An 80-year-old man with castration-resistant prostate cancer (CRPC) and multiple metastatic bone lesions was treated with Ra-223. He was complicated with systemic edema, constipation, and decline of renal function. One week later, he developed pancytopenia which deteriorated gradually, and died with severe prolonged pancytopenia and pneumonia 4 weeks after administration of Ra-223. Our report demonstrates the risk of fatal hematologic toxicity of Ra-223 even though pretreatment clinical and laboratory findings fulfill the selection criteria. Caution should be paid when prescribing Ra-223 to a patient with systemic edema, constipation, and decline of renal function. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
| Yukihiro Hama
Department of Radiology, Edogawa Hospital, Tokyo, Japan
| shoji koga
Department of Urology, Edogawa Hospital, Tokyo, Japan
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| نشانی اینترنتی |
http://crcp.tums.ac.ir/index.php/crcp/article/view/141 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2738/article-2738-2049940.pdf |
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