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، جلد ۷، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of onco-protein Gene Ttransmission |
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| چکیده انگلیسی مقاله |
Background: Bovine leukaemia virus (BLV) is the cause of enzootic bovine leukaemia which belongs to retroviruses including Human T-cell leukaemia virus and simian T-lymphotropic virus. Due to this familiarity, the possibility of virus (BLV) transfer from animal production to humans may exist. Materials and methods: In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR. Results: Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 high grade diffuse large cell lymphoma (B-cell type) samples. Conclusion: These findings explain the possible relation between BLV infection and the occurrence of some types of human lymphomas for the first time. |
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| کلیدواژه‌های انگلیسی مقاله |
BLV, lymphoma, nested PCR, RT-nested-PCR, Tax. |
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| نویسندگان مقاله |
| Camellia Taghadosi
Graduated student, Faculty of Veterinary Medicine, Shahrekord university, Shahrekord, Iran.
| Gholamali Kojouri
Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord university
| Alimohammad Ahadi
Assistant Professor, Department of Genetic, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran.
| Mohammad Hashemi Bahremani
Associate Professor, Laboratory of Pathology, Emam Hosein Hospital, Tehran, Iran.
| Abdolnabi Kojouri
Faculty of Medicine, International Campus of Shahid Sadoughi Medical University, Yazd, Iran
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1102-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
میکروبیولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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