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، جلد ۳، شماره ۴، صفحات ۲۳-۲۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The hepatoprotective effect of Arnebia euchroma hydro-alcoholic extract against liver toxicity induced by CCl4 in mice |
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| چکیده انگلیسی مقاله |
Arnebia euchroma is from Boraginaceae family. Various therapeutic effects have been reported for different species of this plant. The aim of this study was to investigate antioxidant activity of hydroalcoholic extract of the root of A. euchroma and its protective effect on hepatotoxicity induced by CCl4 in mice. In this experimental study, A. euchroma was extracted with ethanol solvent by maceration method. Antioxidant activity of the plant has been evaluated by the DPPH free radical scavenging method. Then, the hepatoprotective effect of A. euchroma was evaluated through determination the content of glutathione in liver tissue, ALP, AST, ALT serum levels and histopathology of liver in different groups. The total phenolic content determined as 0.56% per 100 g of plant was equivalent to gallic acid. The total flavonoid content was 0.079% per 100 g of plant that was equivalent to quercetin. The IC50 of the extract for free radical scavenging was obtained 139.2 µg/ml. The extract increased liver glutathione and serums ALP, AST, ALT that were decreased by CCl4 administration in animal. All protective effects were dose-dependent and the results of liver histopathology showed a significant improvement of inflammation and necrosis that were caused by CCl4 in mice. The results of this study revealed that the hydroalcoholic extract of A. euchroma root has an antioxidant effect and excellent hepatoprotection in mice. |
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| کلیدواژه‌های انگلیسی مقاله |
Hepatoprotective, arnebia euchroma, CCl4, mice |
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| نویسندگان مقاله |
| Mohammad Shokrzadeh
Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
محمد آزادبخت | Mohammad Azadbakht
Pharmaceutical Sciences Research Center, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
مرکز تحقیقات علوم دارویی
| Hamidreza Shakibamanesh
Student Research Committee Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-55-2&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2742/article-2742-2202035.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکوگنوزی |
| نوع مقاله منتشر شده |
پژوهشی |
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