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، جلد ۳، شماره ۲، صفحات ۱۹-۲۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protective effect of selenium against aluminium chloride induced cardiotoxicity in rats |
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| چکیده انگلیسی مقاله |
Our study pertains to evaluate the protective effect of selenium (Se), used as a nutritional supplement, against aluminium chloride induced cardiotoxicity in rats. Rats have received during 21 days either AlCl3 (400 ppm) via drinking water, AlCl3 associated with Na2SeO3 (0.5 mg/kg of diet) or only Na2SeO3. Co-administration of Se to AlCl3 treated rats alleviated heart oxidative stress objectified by a decrease of malondialdehyde, hydrogen peroxide and protein carbonyls levels. An improvement in antioxidant redox status, enzymatic (catalase, superoxide dismutase and glutathione peroxidase) and non enzymatic (reduced glutathione, non protein thiols and vitamin C) was also observed in Se treated rats. LDH and CK activities, TC, LDL-C levels, TC/HDL-C and LDL-C/HDL-C ratios were increased, while HDL-C and TG decreased in rats treated with AlCl3. Cardiac biomarkers and lipid profile were restored to near control values by the supplementation of Se. Our results revealed that Se, a trace element with antioxidant properties, was effective in preventing heart damage induced by aluminium chloride. |
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| کلیدواژه‌های انگلیسی مقاله |
Aluminium, rats, oxidative stress, selenium, heart |
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| نویسندگان مقاله |
| Imen Ghorbel
Animal Physiology Laboratory. Sciences Faculty of Sfax. University of Sfax, BP 1171, 3000 Sfax, Tunisia
| Awatef Elwej
Animal Physiology Laboratory. Sciences Faculty of Sfax. University of Sfax, BP 1171, 3000 Sfax, Tunisia
| Mariem Chaabane
Animal Physiology Laboratory. Sciences Faculty of Sfax. University of Sfax, BP 1171, 3000 Sfax, Tunisia
| Kamel Jamoussi
Biochemistry Laboratory, CHU Hedi Chaker, University of Sfax, 3029 Sfax, Tunisia
| Najiba Zeghal
Animal Physiology Laboratory. Sciences Faculty of Sfax. University of Sfax, BP 1171, 3000 Sfax, Tunisia
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-145-2&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2742/article-2742-2202043.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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