|
|
، جلد ۲، شماره ۱، صفحات ۴۴-۵۴
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Encapsulation of nystatin in nanoliposomal formulation: characterization, stability study and antifungal activity against Candida albicans |
|
| چکیده انگلیسی مقاله |
In this study, nystatin liposomal formulation was prepared and characterized. The physicochemical properties of formulations including vesicle size, drug entrapment stability and in vitro release were studied. The highest entrapment efficiency of nystatin into liposomes was obtained about 70% when cholesterol (CHO) was added to the formulations prepared with dipalmitoylphosphatidylcholine. In addition, the drug entrapment efficiency was decreased when distearoylphosphatidylcholine was used but it was improved by addition of CHO and hydration with 9% sucrose solution. Liposomes with uniform size distribution and average size of 100 nm were produced. Long term stability study indicated that the lyophilized liposomal nystatin was physically stable for at least 6 months at 4 °C. In vitro anti-fungal activity of liposomal nystatin was found to be more effective than free nystatin against Candida albicans. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
| Ebrahim Saadat
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
| Rassoul Dinarvand
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
| Pedram Ebrahimnejad
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
|
|
| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-62-2&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2742/article-2742-2202081.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماسیوتیکس |
| نوع مقاله منتشر شده |
پژوهشی |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|