، جلد ۱، شماره ۳، صفحات ۵۹-۷۰
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چکیده فارسی مقاله
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عنوان انگلیسی Improving the dissolution properties of spironolactone using liquisolid technique
چکیده انگلیسی مقاله In this study the effect of liquisolid technique on the dissolution profile of spironolactone was evaluated. Different formulations of spironolactone liquisolid compacts were prepared using various amounts of non-volatile vehicles (Poly ethylene glycol 400 and glycerin). The ratio of microcrystalline cellulose (as carrier) to silica (as coating powder material) was 20 for all formulations. After preparing tablets by direct compression with constant compression load, the release profiles were evaluated by USP paddle method. Differential scanning calorimeter (DSC) and FTIR were used to evaluate any interaction between spironolactone and other ingredients. The liquisolid tablets exhibited significantly higher dissolution rates in comparison with conventionally direct compressed tablets. Furthermore results showed dissolution rate enhancement of liquisolid tablets by increase in the amounts of non-volatile vehicles. Differential scanning calorimetry showed that, the drug has got solubilized in the liquid vehicle. FT-IR spectroscopy studies of pure spironolactone, liquisolid compacts, glycerin and PEG400 supported solubilization of the drug in the liquid vehicle too. The FT-IR spectra also showed that no interactions have been occurred between spironolactone and other ingredients. In conclusion the liquisolid technique can be a suitable method in order to prepare rapid release tablets of poorly water-soluble drugs such as spironolactone.
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نویسندگان مقاله | Jafar Akbari
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Majid Saeedi
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran


| Katayoun Morteza-Semnani
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Zaynab Sadeghi Ghadi
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran


| Seyed Saeed Hosseini
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
نشانی اینترنتی http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-24&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/2742/article-2742-2202095.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فارماسیوتیکس
نوع مقاله منتشر شده پژوهشی
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