Basic and Clinical Neuroscience، جلد ۱۰، شماره ۶، صفحات ۲-۲
عنوان فارسی
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عنوان انگلیسی Protective Role of Apigenin Against Aβ 25-35 Toxicity Via Inhibition of Mitochondrial Cytochrome c Release
چکیده انگلیسی مقاله Introduction: Cognitive dysfunction is the most common problem of patients with Alzheimer disease (AD). The pathological mechanism of cognitive impairment in AD may contribute to neuronal loss, synaptic dysfunction, and alteration in neurotransmitters receptors. Mitochondrial synapses dysfunction due to the accumulation of amyloid beta (Aβ) is one of the earliest pathological features of AD. The flavone apigenin has been reported to play some protective roles in AD through the anti-oxidative and anti-inflammatory properties. This study aimed at investigating the effects of apigenin on spatial working memory and neural protection by restoring mitochondrial dysfunction and inhibition of caspase 9. Methods: Intracerebroventricular (ICV) microinjection of Aβ 25-35 was used for AD modeling. Working memory was assessed 21 days later using the Y maze test. Neuronal loss was detected in the hilar area of the hippocampus using Nissl and Fluoro-jade B staining, whereas immunohistochemistry was used to illustrate cytochrome c positive cells and caspase 9. Results: The results revealed that apigenin significantly ameliorated spatial working memory. It also significantly reduced the number of degenerative neurons in the hilus area. Apigenin almost completely blocked the release of cytochrome c and caspase 9 in hilus. Conclusion: Apigenin may improve the spatial working memory deficits and neuronal degeneration through the amelioration of the mitochondrial dysfunction.
کلیدواژه‌های انگلیسی مقاله Apigenin, Alzheimer, Memory, Cytochrome c
نویسندگان مقاله | Farnaz Nikbakht
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.


| Yasaman Khadem
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Sobhan Haghani
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Hadiseh Hoseininia
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Alireza Moein sadat
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Paria Hashemi
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


| Nida Jamali
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-126-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cellular and molecular Neuroscience
نوع مقاله منتشر شده Original
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