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Anatomical Sciences Journal، جلد ۷، شماره ۲۸، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Study of Neuroprotective Effects of Green Tea Antioxidant on Spinal Cord Injury of Rat |
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| چکیده انگلیسی مقاله |
Purpose: Recent studies revealed the neuroprotective effects of green tea antioxidant on experimental cerebral ischemia, but these effects on spinal cord injury (SCI) has not yet been studied.Materials and Methods: Rats were randomly divided into three groups of 18 rats each as follows: sham group (laminectomy), control group (SCI) and experimental group (EGCG). Spinal cord samples were taken 24 h after injury and studied for determination of lipid peroxidation levels and TUNEL reaction. Behavioral testing was performed weekly upto six weeks post-injury. Then, the rats were euthanized for histopathological assessment.Results: The results showed that lipid peroxidation levels were significantly decreased in experimental group. EGCG significantly reduced TUNEL-positive rate. Also, EGCG reduced significantly lesion area, and improved behavioral function more than the control group.Conclusion: EGCG treatment decreased secondary spinal cord injury. |
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| کلیدواژه‌های انگلیسی مقاله |
Pigallocatechin Gallate (Egcg), Spinal Cord Injury, Immunohistochemistry |
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| نویسندگان مقاله |
| Ali Reza Khalatbari
| Taghi Altiraihi
| Mandana Beygi Boroujeni
| Hassan Ahmadvand
| Majid Tavafi
| Ahmad Tamjidipour
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| نشانی اینترنتی |
http://anatomyjournal.ir/browse.php?a_code=A-10-304-192&slc_lang=fa&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Morphometry |
| نوع مقاله منتشر شده |
Original |
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