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Anatomical Sciences Journal، جلد ۷، شماره ۲۸، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Histological Analysis Antimetastatic Effect of Intera -Venus Injection of Staphylococcal Enterotoxin B and Monophosphoryl Lipid A Against Fibrosarchoma in Lung Tissue |
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| چکیده انگلیسی مقاله |
Purpose: Staphylococcal enterotoxin B (SEB) is a potent inducer of cytotoxic T-cell activity, cytokine production and necrosis induction in vivo. Monophosphoryl lipid A (MPL) is an adjuvant derived from the lipopolysaccharide of E.coli, Salmonella Minnesota Re595 and other gram negative bacteria.Materials and Methods: In this research, The antitumor and antimetastatic effect of intra-venus injection of Monophosphoryl Lipid A (MPL), staphylococcal enterotoxin B (SEB) and SEB+MPL was evaluated using Balb/C male mice bearing inoculable mice Fibrosarcoma. The anti tumor effect of SEB+MPL, SEB and MPL in mice with inoculated fibrosarchoma tumor (Wehi-164) was examined by IV injection and the sizes of the inoculated tumors were determined. The inoculated tumors were also examined histologically. Moreover, histophatologic study in lung tissue didn't show any metastasis.Results: In the mice IV injected group with SEB+MPL, reduction of tumor size show a significant difference compared with mice in the SEB and MPL injected and negative control group. A significantly higher frequency of necrosis in tumor tissues was also observed in mice in the IV (SEB+MPL)-injected group in comparison with other group. Moreover, histophatologic study in lung tissue didn't show any metastasis.Conclusion: Our findings suggest that tumor cell death and the prevention of metastasis be caused by increased Cytotoxic T-cell activity in response to IV injection of SEB+ MPL that need to more investigation. |
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| کلیدواژه‌های انگلیسی مقاله |
Staphylococcal Enterotoxin B (Seb), Monophosphoryl Lipide A(Mpl), Fibrosarchoma, Lung Metastasis |
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| نویسندگان مقاله |
| Abbas Ali Imani Fouladi
| Mohammad Reza Nourani
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| نشانی اینترنتی |
http://anatomyjournal.ir/browse.php?a_code=A-10-304-190&slc_lang=fa&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Morphometry |
| نوع مقاله منتشر شده |
Original |
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