|
|
Anatomical Sciences Journal، جلد ۵، شماره ۱۸، صفحات ۱-۸
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Neuroprotective Effect of Mitochondrial Katp Channel Opener Upon Neuronal Cortical Brain of Rat Population |
|
| چکیده انگلیسی مقاله |
Purpose: So far there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied effects of The Mitochondrial K-ATP channel regulators on neuronal cell population and neurological function after ischemia reperfusion in the rat. Materials and Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. Neurological assessment was conducted after 24h reperfusion by consciousness scoring and motor function according to the methods reported by Lemay and Tarloe. After tissue processing and crysel violet staining total and normal cell number was assessed in parietal cortex.Data was analyzed by ANOVA software. Results: The normal cell count of neuronal population significantly increased in the K-ATP channel opener (Diazoxide) treated ischemia-reperfusion group compared with the control group. Cell count and neurological function scores were dependent to dose of K-ATP channel regulators in vivo. Conclusions: Our results showed that Diazoxide treatment leads to better preservation of cortical neurons in rat. |
|
| کلیدواژه‌های انگلیسی مقاله |
K-ATP channel openers, Ischemia reperfusion injury |
|
| نویسندگان مقاله |
| Mansoureh Soleimani
| Mahdi Mahdi Zadeh
Anatomy Department, Medical Faculty, Iran Medical Sciences University, Tehran, Iran.
| Masoomeh Bakhshayesh
| Sara Soleimani
| Parvaneh Tabatabaei
|
|
| نشانی اینترنتی |
http://anatomyjournal.ir/browse.php?a_code=A-10-304-154&slc_lang=fa&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Morphometry |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|