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Anatomical Sciences Journal، جلد ۳، شماره ۳، صفحات ۲۰۳-۲۱۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Morphometric Changes of Rat Testis After Subchronic Oal Lead Intoxication and D-Penicillamine Treatment |
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| چکیده انگلیسی مقاله |
Purpose: The aim of this study was to assess the efficacy of D-Penicillamine in reducing lead induced morphometric changes in rat testis. Materials and Methods: Male adult rats were exposed to 0.4% lead acetate in drinking water for 8 weeks. After this period, 6 rats sacrificed and testes were removed to evaluate the effects of lead intoxication. The remained lead exposed rats were divided into two groups: one group received distilled water and the other group received 25-35 mg/kg/day of oral D-p treatment for six weeks, after one week of recovery. Testis morphometric changes were studied in H&E stained sections. Results: Width of germinal epithelium and number of sertoli cells were decreased after 8 weeks of lead intoxication (P< 0.05). These parameters were still significantly lower than control group after both of recovery and treatment periods (P< 0.05). Conclusion: This study showed that subchronic oral lead intoxication induces some changes in adult testis which are not reversible even after D-P administration. |
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| کلیدواژه‌های انگلیسی مقاله |
Lead Toxicity, Testis, Recovery, D-penicillamine, Rat |
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| نویسندگان مقاله |
| Danial Roshan del
Anatomy & Histology Department, Gorgan Medical Faculty, Gorgan, Iran.
| Margan Kalavi
| Soraya Ghaffari
| Mohammad Gharavi
| Gholam Reza Roshan Del
| Mohammad Jafar Gol Ali Poor
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| نشانی اینترنتی |
http://anatomyjournal.ir/browse.php?a_code=A-10-304-114&slc_lang=fa&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Morphometry |
| نوع مقاله منتشر شده |
Original |
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