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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۶، صفحات ۷۱۱-۷۲۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Association Between Fennel Extract, Serum Lipid Profile, and Leptin Receptor Expression |
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| چکیده انگلیسی مقاله |
Introduction: Obesity is among the most severe challenges of our era, with significant health consequences and a high economic burden for health systems. Therefore, many countries have developed political agendas to cope with this ever-rising challenge. Along with chemical medications developed to manage obesity, researchers have focused on some natural ingredients and herbal extracts that are effective in reducing weight. The current study investigated the association between Foeniculum vulgar (fennel) extracts and body weight, lipid profile, and leptin. Methods: In total, 35 adult male BALB/c mice were investigated in sham, fennel 50 mg/kg, fennel 100 mg/kg, and fennel 200 mg/kg (n=7) groups. The mice were administered fennel extracts for fourteen days while weighted at the intervention's beginning and end. Then, their weight, lipid profile, serum leptin, and expression of leptin protein in the hypothalamus were measured. Results: After providing the intervention, leptin receptor protein expression was increased in all groups, while serum leptin didn't change significantly. Moreover, a significant decrease was observed in the cholesterol dose of 100 mg/kg/day, triglycerides in 100 and 200 mg/kg/day, and LDL in 50 and 100 mg/kg/day. Serum HDL was increased significantly in a dose of 100 mg/kg/day. Conclusion: Fennel extract can decrease the lipid profile by changing the expression of the leptin receptor. |
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| کلیدواژه‌های انگلیسی مقاله |
Fennel, Foeniculum vulgare, Lipid profile, Leptin, Hypothalamus, Obesity |
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| نویسندگان مقاله |
| Forogh Zakernezhad
Department of Cellular and Molecular Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
| Mahmood Barati
Department of Biotechnology, School of Allied Medicine, Iran University of Medical Science, Tehran, Iran.
| Nima Sanadgol
Department of Biology, School of Sciences, University of Zabol, Zabol, Iran.
| Monireh Movahhedi
Department of Cellular and Molecular Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
| Ahmad Majd
Department of Cellular and Molecular Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
| Fereshteh Golab
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-998-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
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