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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۵، صفحات ۶۶۷-۶۷۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity |
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| چکیده انگلیسی مقاله |
Introduction: Oxidative stress plays a critical role in the pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior has not been clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city. Methods: Fifty suicide attempters and 40 control subjects (volunteers) aged 18-35 years were studied in the current experiment. To consider the oxidant-antioxidant status, serum levels of Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide Dismutase (SOD), and the Total Antioxidant Capacity (TAC) were measured. Results: Serum levels of SOD and TAC were significantly lower in the suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters compared to the control groups. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the control groups. Conclusion: The oxidative stress without MDA elevation, detected in suicide attempters, can be considered a biochemical hallmark in suicide behavior. |
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| کلیدواژه‌های انگلیسی مقاله |
Suicide behavior, Oxidative stress, TAC, MDA, SOD |
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| نویسندگان مقاله |
| Mahin Oshnokhah
Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
| Maryam Bagheri
Department of Physiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
| Hori Ghaneialvar
Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
| Karimeh Haghani
Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
| Ali Khorshidi
Department of Epidemiology, Ilam University of Medical Sciences, Ilam, Iran.
| Ali Shahbazi
Department of Neuroscience, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Sajjad Salari
Department of Physiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1917-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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