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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۵، صفحات ۶۷۵-۶۸۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Transcranial Direct Current Stimulation on Dorsolateral Prefrontal Cortex to Reduce the Symptoms of the Obsessive-Compulsive Disorder |
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| چکیده انگلیسی مقاله |
Introduction: Obsessive-Compulsive Disorder (OCD) is one of the most common debilitating mental disorders with a prevalence rate of 2% to 3% in the general population. Previous studies have indicated abnormalities in the dorsolateral prefrontal cortex (DLPFC) of OCD patients; thus, we decided to use transcranial Direct Current Stimulation (tDCS) to decline these patients' symptoms. Methods: A total of 24 patients with OCD participated in this study with the hope of improvement after the application of tDCS. The subjects were randomly assigned to three groups of Sham, Right DLPFC, and Left DLPFC. tDCS was applied for five consecutive days and in each session, patients were subjected to 2 mA current flow for two 15 minutes followed by a 10-minute rest in between (every session lasted for 40 minutes). Results: Subsequently, the changes in obsessive-compulsive level and cognitive functions were evaluated via Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and Depression, Anxiety, and Stress Scale 21 (DASS-21) by comparing the results before (pre-test) and after (post-test) tDCS treatment. Conclusion: Ultimately, the scores of the Yale-Brown scale in the Left DLPFC group showed significant changes after treatment with tDCS (mean difference compared to the sham group: -6.18 and P≤0.05). Hereupon, this study demonstrated that transcranial direct current stimulation may cause improvements in symptoms of OCD. |
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| کلیدواژه‌های انگلیسی مقاله |
Obsessive-Compulsive Disorder, Dorsolateral prefrontal cortex, Transcranial direct current stimulation, Yale-Brown test |
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| نویسندگان مقاله |
| Sina Shafiezadeh
Institute for Cognitive Science Studies, Tehran, Iran.
| Mansoureh Eshghi
Institute for Cognitive Science Studies, Tehran, Iran.
| Zahra Dokhaei
Institute for Cognitive Science Studies, Tehran, Iran.
| Hossein Mohajeri
Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
| Atiyeh MohammadShirazi
Department of Brain and Cognitive Science, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
| Sara Mirsadeghi
Department of Brain and Cognitive Science, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
| Peyman Hasani Abharian
Institute for Cognitive Science Studies, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1920-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cognitive Neuroscience |
| نوع مقاله منتشر شده |
Original |
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