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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۵، صفحات ۶۸۱-۶۹۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A Neurochemical and Electrophysiological Study on the Combined Effects of Caffeine and Nicotine in the Cortex of Rats |
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| چکیده انگلیسی مقاله |
Introduction: Caffeine and nicotine are the most widely consumed psychostimulants worldwide. Although the effects of each drug alone on the central nervous system have been studied extensively, the literature on the neurochemical and electrophysiological effects of their combined treatments is scarce. The present study investigated the cortical electrophysiological and neurochemical alterations induced by acute administration of caffeine and nicotine in rats. Methods: The rats received caffeine and nicotine at a 1-hour interval between the two treatments. Results: Caffeine and nicotine administration resulted in a significant decrease in the concentrations of cortical amino acid neurotransmitters, namely glutamate, aspartate, glycine, and taurine, while γ-aminobutyric acid (GABA) significantly increased. Increased cortical lipid peroxidation and reduced glutathione and nitric oxide levels and acetylcholinesterase and Na⁺/K⁺-ATPase activities were also observed. The Electroencephalogram (EEG) showed an increase in delta frequency power band, whereas theta, beta-1, and beta-2 decreased after caffeine and nicotine treatment. Conclusion: These findings suggest that caffeine and nicotine adversely exacerbate their stimulant effects manifested by the EEG changes mediated by increasing cholinergic transmission and disturbing the balance between the excitatory and inhibitory amino acids leading to oxidative stress. |
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| کلیدواژه‌های انگلیسی مقاله |
Caffeine, Nicotine, Electroencephalogram, Oxidative stress, Amino acid neurotransmitters |
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| نویسندگان مقاله |
| Iman M. Mourad
Department of Zoology, School of Science, Cairo University, Egypt.
| Neveen A. Noor
Department of Zoology, School of Science, Cairo University, Egypt.
| Haitham S. Mohammed
Department of Biophysics, School of Science, Cairo University, Egypt.
| Heba S. Aboul Ezz
Department of Zoology, School of Science, Cairo University, Egypt.
| Yasser A. Khadrawy
Department of Medical Physiology, Medical Division, National Research Center, Egypt.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2100-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
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