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Basic and Clinical Neuroscience، جلد ۱۱، شماره ۴، صفحات ۴۱۳-۴۲۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Ibuprofen Protection Against Restrained Chronic Stress-induced Depression in Male Rats |
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| چکیده انگلیسی مقاله |
Introduction: Stress predisposes organisms to depression and cognitive impairments, and seems to interact with metabolic homeostasis. The inflammatory response and the upregulation of proinflammatory cytokines are some of the consequences related to chronic stress. In this study, we investigated the preventive effect of chronic administration of ibuprofen, as an inhibitor of cyclooxygenases, on the cognitive and behavioral alterations and the weight gain reduction induced by simultaneous chronic restraint stress in rats. Materials and Methods: Male Wistar rats were subjected to chronic restraint stress and injected daily with the variable doses of ibuprofen or vehicle, for 21 consecutive days. Then, all animals were tested with the forced swim test and passive avoidance conditioning. Also, the weight of the animals was recorded before and after the interventions. Ultimately, plasma interleukin 6 (IL-6) levels were measured. Results: Chronic stress increased depressive-like behaviors, impaired learning, and disrupted the normal weight gain. However, the animals that received the highest dose of ibuprofen showed less depressive-like behaviors, a better avoidance memory, and a higher weight gain. However, the level of plasma IL-6 did not differ significantly between the study groups. Conclusion: The administration of ibuprofen prevents the cognitive and behavioral consequences of chronic stress. During the recovery, the plasma levels of IL-6 were not elevated by stress, and the IL-6 levels did not predict the behavioral performance of the stressed animals. The exact mechanisms of the protective effects of ibuprofen against chronic stress need to be further investigated. |
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| کلیدواژه‌های انگلیسی مقاله |
Depression, Ibuprofen, Passive avoidance, IL-6, Forced swimming test |
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| نویسندگان مقاله |
| Masoumeh Nozari
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
| Arezo Nahavandi
Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Motahareh Zeinivand
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Maryam Eslami Gharaati
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Mina Godarzi
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Mohammad Ahmadi
Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.
| Nida Jamali-Raeufy
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1775-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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