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Caspian Journal of Neurological Sciences، جلد ۷، شماره ۴، صفحات ۱۹۳-۲۰۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats |
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| چکیده انگلیسی مقاله |
Background: Aortic artery stenosis leads to Ischemia-Reperfusion (I-R) injury, which can cause certain clinical expressions, such as paraplegia. Objectives: To appraise the effect of Catechin Hydrate (CH) against spinal cord I-R injury. Materials & Methods: A total of 35 male rats (250-300 g) were divided randomly into five groups: intact, sham surgery, dimethyl sulfoxide (I-R+DMSO), low-dose CH (I-R+10 mg/kg CH), and high-dose CH (I-R+20 mg/kg CH). Abdominal aorta clamping was done for 60 min. Seventy-two hours after I-R, animals were evaluated for neurologic function, biochemical analysis, and histology. The data analysis was conducted by SPSS v. 16 using ANOVA and Kruskal-Wallis and Mann-Whitney U tests. Results: The mean Motor Deficit Index (MDI) score and white matter damage in the CH (20 mg/kg) group were lower than in the DMSO group (P=0.032). The mean plasma levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in the CH groups were lower than that of the DMSO group (P< 0.05). The plasma level of Total Antioxidant Capacity (TAC) in the CH (20 mg/kg) group was higher than in the DMSO group (P=0.032). In addition, the plasma level of catalase in the CH (20 mg/kg) group was higher than in the DMSO and CH (10 mg/kg) groups (P< 0.001). The average number of normal motor neurons in the experimental groups was lower than in the sham surgery group (P< 0.001). Conclusion: These results showed that CH may be effective in reducing spinal cord I-R injury. |
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| کلیدواژه‌های انگلیسی مقاله |
Spinal cord injuries, Antioxidants, Ischemia, Reperfusion, Rats |
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| نویسندگان مقاله |
| Naser Hajizadeh
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
| Gholam Hossein Farjah
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
| Mojtaba Karimipour
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
| Bagher Pourheidar
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
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| نشانی اینترنتی |
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-143&slc_lang=en&sid=1 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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