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، جلد ۸، شماره ۳، صفحات ۱۴۷-۱۵۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject |
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| چکیده انگلیسی مقاله |
Background: Currently, glycans, which are known as functional molecules in the biological system, are being under study as potential cancer markers. This study aimed to determine the level of serum L-fucose and sialic acid as the biomarkers in patients with colorectal cancer (CRC). Materials and Methods: The patients with CRC (n=40, 20 men and 20 women) participated in the present study. The spectrophotometric method was used to measure the levels of L-fucose and sialic acid in the serum of the patients. SPSS (version 21) was used to analyze the obtained data. The results were expressed as mean ± SD. Results: The mean ± SD L-fucose level in patients with CRC was 27.46 ± 4.8 ng/mL, which was more than this level in the healthy control group (18.64±3.1 ng/mL). Also, the mean ± SD serum concentration of sialic acid in patients with CRC was 2.1 ± 0.41 ng/mL, which was more than the mean ± SD sialic acid level of 1.23±0.21 ng/mL in the healthy controls. Conclusion: Serum concentration of L-fucose and sialic acid increased significantly (P < 0.05) in patients with CRC compared with the healthy controls. We believe that determining serum L-fucose and sialic acid levels could be useful for the detection of CRC patients in the early stage. |
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| کلیدواژه‌های انگلیسی مقاله |
Colorectal cancer, glycosylation, serum markers |
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| نویسندگان مقاله |
| Roya Abbasinatajomrani
Department of Biology, Payame Noor University, Tehran, Iran
| Durdi Qujeq
Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
| Vahid Hosseini
Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran
| Reza Hajihosseini
Department of biochemistry, Payame Noor University, Tehran, Iran
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-609-7&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
بیوشیمی |
| نوع مقاله منتشر شده |
پژوهشی |
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