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، جلد ۸، شماره ۴، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Inhibitors of α-glucosidase and Angiotensin Converting Enzyme in the therapeutic treatment of Type2 Diabetes and complications: A review on in silico approach |
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| چکیده انگلیسی مقاله |
Background: The use of pharmacological agents to synergistically target key enzymes associated with carbohydrate digestion (α-glucosidase) and the hypertension-related Angiotensin-Converting Enzyme (ACE) are critical strategies towards the management of type-2 diabetes (T2D) and its end-stage complications. Furthermore, aside from their blood pressure-lowering effect, ACE inhibitors (ACEIs) are important therapeutic agents for preventing diabetic complications, highlighting their synergistic renoprotective and antihypertensive effects in diabetic patients who are normotensive and hypertensive. Objectives: The article aims to review the safety and potent activity of phytochemicals discovered based on Molecular docking and dynamics in recent years that could be used to treat type2-DM. Methods: We survey recent in silico drug discovery findings on α-glucosidase and ACE retrieved from the PubMed database. Computational in silico ADMET meta-analysis was performed on 57 compounds that could potentially inhibit α-glucosidase or ACE. Results: The review highlights the fact that most hit compounds of α-glucosidase and ACE involving the use of molecular docking and molecular dynamics techniques are competitive and peptide inhibitors, respectively. Moreover, we found out that most authors do not put ADMET (Absorption Distribution Metabolism Excretion Toxicity) studies of drug candidates into consideration which is important in determining the safety profile of potent leads. Hence, we performed in silico ADMET meta-analysis of the reported compounds and found some inhibitors with an excellent pharmacological profile. Conclusion: We propose that further studies be conducted on these Promising leads to demonstrate their efficacy and safety in the treatment of Type2-DM. |
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| کلیدواژه‌های انگلیسی مقاله |
α-glucosidase, angiotensin-converting enzyme, in silico drug discovery, Pharmacological activity, ADMET |
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| نویسندگان مقاله |
| Temitope Adelusi
| Abdul-Quddus Oyedele
| Ibrahim Boyenle
| Abdeen Ogunlana
| Mojeed Ashiru
| Opeyemi Atanda
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1052-1&slc_lang=en&sid=1 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
طراحی دارو |
| نوع مقاله منتشر شده |
مروری |
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