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، جلد ۸، شماره ۳، صفحات ۱۷۹-۱۸۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protective Effects of N-Acetylcysteine on Dipentyl Phthalate Induced Cognitive Dysfunction and Brain Oxidative Stress in Mice |
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| چکیده انگلیسی مقاله |
Background: Dipentyl phthalate (DPeP) is a plasticizer compound commonly used in polyvinylchloride plastic to enhance softness and flexibility. They are not bound covalently to plastic polymers; therefore, they can dissolve into the environment and adversely affect the health of humans and animals. Objectives: The aim of this study was to investigate the effect of DPeP on cognition and protective effects of N-acetylcysteine (NAC) on DPeP induced alteration in cognitive behaviour and oxidative stress markers in mice. Methods: Mice were orally treated with 2 doses (33 mg/kg and 100 mg/kg) of DPeP for 28 days. Cognitive functions were assessed using spatial navigation tasks on the Morris water maze and the step-down latency in the passive avoidance apparatus. Oxidative stress was assessed by examining the levels of malondialdehyde, glutathione, ferric reducing antioxidant power, and 8-hydroxy-deoxyguanosine levels in the whole brain of mice. Results: There was a significant increase in latency in spatial navigation tasks and a significant decline in the step-down latency in passive avoidance apparatus in the DPeP-treated group compared to the control groups. There was also a significant increase in the levels of oxidative stress following DPeP administration as seen with the rise in the levels of malondialdehyde, 8-hydroxy-deoxyguanosine, and a fall in glutathione and ferric reducing antioxidant power levels. Conclusion: The present study demonstrated that DPeP adversely affects learning and memory functions in mice by oxidative stress-mediated neuronal damage. These effects were attenuated by pretreatment with N-acetylcysteine. |
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| کلیدواژه‌های انگلیسی مقاله |
Phthalate, Oxidative stress, N-acetylcysteine, Reactive oxygen species |
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| نویسندگان مقاله |
| Sandhya Rani Gautam
Department of Pharmacology, University College of Medical Sciences & GTB Hospital, Delhi.
| Seema Jain
Department of Pharmacology, University College of Medical Sciences & GTB Hospital, Delhi.
| Proteesh Rana
Department of Pharmacology, University College of Medical Sciences & GTB Hospital, Delhi.
| Basudev Banerjee
Department of Biochemistry, University College of Medical Sciences & GTB Hospital, Delhi.
| Pramod Kumari
Department of Pharmacology, University College of Medical Sciences & GTB Hospital, Delhi.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-510-3&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
سم شناسی |
| نوع مقاله منتشر شده |
پژوهشی |
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