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، جلد ۷، شماره ۴، صفحات ۲۷۱-۲۷۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Phytochemical Screening and Antinociceptive Activity of the Hydroalcoholic Extract of Potentilla reptans L. |
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| چکیده انگلیسی مقاله |
Background: Potentilla species have traditionally been used as anti-inflammatory and analgesic agents in Iran and other countries. Objectives: This study aimed to investigate the antinociceptive effect of Potentilla reptans L., which has a wide distribution in the north of Iran. Methods: The biological activities of the hydroalcoholic extract of P. reptans aerial parts have been investigated using the acetic acid-induced writhing, hot plate, and rotarod tests in the male mice. In addition, the phytochemical profile of the extract has been evaluated. Results: The phytochemical investigation detected secondary metabolites such as flavonoids, saponins, triterpenoids, and tannins in the extract. Moreover, the Mean±SD total phenolic and tannin contents of the extract were 251±2.08 and 111.5±1.3 mg gallic acid equivalents per gram of dried extract, respectively. Also, the Mean±SD total flavonoid content was 29.42±3.31 mg quercetin equivalents per gram of dried extract. Oral administration of the extract (100, 300, and 500 mg/kg) dose-dependently reduced the number of writhing responses induced by acetic acid and increased the reaction time in the hot-plate test. The antinociceptive effect of the extract, similar to morphine, was significantly antagonized by naloxone (4 mg/kg; IP) in the writhing test. In the rotarod test, none of the extract doses used in the experiment caused a loss of locomotor activity. Conclusion: In this study, the hydroalcoholic extract of P. reptans showed a practical antinociceptive effect in hot plate and writhing tests. It seems that opioid receptors mediate the observed effect. |
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| کلیدواژه‌های انگلیسی مقاله |
Analgesics, Potentilla, Rotarod test, Opioid receptors, Phenols |
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| نویسندگان مقاله |
| Nematollah Ahangar
Department of Pharmacology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
| Hossein Bakhshi Jouybari
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
| Ali Davoodi
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
| Somayeh Shahani
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-49-2&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکوگنوزی |
| نوع مقاله منتشر شده |
پژوهشی |
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