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، جلد ۷، شماره ۱، صفحات ۲۵-۳۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Inhibitory Effects of Salinispora-derived Metabolites Against Multidrug Resistance: An In-silico Study |
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| چکیده انگلیسی مقاله |
Background: Multi drug resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression or overactivation of ATP-binding cassette (ABC) transporters, especially P-glycoprotein (P-gp), in the development of chemotherapy has long been demonstrated. Salinispora is a marine actinomycete genus known for the production of novel bioactive metabolites. Objectives: In this study, the potential of Salinispora derived metabolites as inhibitor of ATP-binding cassette (ABC) transports have been investigated using in-silico approaches. Methods: Physicochemical, pharmacokinetic and drug likeness of the Salinispora derived metabolites have been analyzed using SwissADME server. This was accompanied by the employment of docking strategy to evaluate anti-MDR potential of the metabolites using P-gp, Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Protein 1 (MRP-1) as target proteins. Results: Nineteen metabolites were found to have demonstrated appropriate physicochemical, pharmacokinetic, and drug-likeness properties and were involved in the docking studies. Based on docking studies, saliniquinones, cyclomarazine, and cyanosporoside A demonstrated ABC transporters inhibitory potential. Conclusion: Our results suggest that further in vivo and in vitro studies on anti-MDR effects of Salinispora-derived metabolites are warranted. |
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| کلیدواژه‌های انگلیسی مقاله |
Multidrug resistance, Docking, Salinispora, Neoplasms, P-glycoprotein |
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| نویسندگان مقاله |
| Morteza Ghandadi
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-407-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
طراحی دارو |
| نوع مقاله منتشر شده |
پژوهشی |
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