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Basic and Clinical Neuroscience، جلد ۱۳، شماره ۶، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The association between inflammatory biomarkers and vitamin D level with the evolution and severity of stroke |
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| چکیده انگلیسی مقاله |
Background and purpose: Vitamin D deficiency has been linked to the evolution of ischemic stroke, but the data regarding the association between stroke severity and vitamin D level is scarce. Materials and methods: Patients with first-ever ischemic stroke in the middle cerebral artery territory, within seven days after the stroke, were recruited. The control group included age- and gender-matched individuals. We compared 25-OH vitamin D (vitamin D), high sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), and osteopontin levels between stroke patients and the control group. The association between stroke severity according to the National Institutes of Health Stroke Scale (NIHSS) and the Alberta stroke program early CT score (ASPECTS) and levels of vitamin D and inflammatory biomarkers were also studied. Results: There was an association between hypertension (P= 0.035), diabetes mellitus (P= 0.043), smoking (P= 0.016), history of ischemic heart disease (P= 0.002), higher SAA (P< 0.001), higher hsCRP (P< 0.001), and lower vitamin D levels (P= 0.002) and stroke evolution in a case-control study. Meanwhile, in stroke patients, its severity was associated with higher SAA (P= 0.04) and hsCRP (P= 0.001), and lower vitamin D levels (P value= 0.043) according to clinical scale (higher admission NIHSS). According to the ASPECT score, higher SAA (P= 0.017) and hsCRP (P= 0.007), but not lower vitamin D levels, were associated with more infarct areas (P= 0.149). Conclusion: Vitamin D may play a role in both the evolution and severity of stroke. |
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| کلیدواژه‌های انگلیسی مقاله |
Ischemic stroke, Cerebrovascular accident, Vitamin D, high sensitive C-reactive protein, Serum Amyloid A, Osteopontin |
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| نویسندگان مقاله |
| Anahid Safari
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
| Nima Fadakar
Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
| Afshin Borhani-Haghighi
Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1971-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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