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Basic and Clinical Neuroscience، جلد ۱۳، شماره ۶، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Brain Structural Covariance Network in Asperger Syndrome Differs From Those in Autism Spectrum Disorder and Healthy Controls |
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| چکیده انگلیسی مقاله |
Autism is a heterogeneous neurodevelopmental disorder associated with social, cognitive, and behavioral impairments. These impairments are often reported along with alterations of the brain structure such as abnormal changes in the grey matter (GM) density. However, it is not yet clear whether these changes could be used to differentiate various subtypes of autism spectrum disorder (ASD). In this study, we compared the regional changes in GM density in ASD, Asperger syndrome (AS) individuals, and a group of healthy controls (HC). In addition, regarding the regional changes, the amount of GM density changes in one region compared to other brain regions was also calculated. We hypothesized that this structural covariance network could differentiate AS group from the ASD and HC groups. Therefore, statistical analysis was performed on the magnetic resonance imaging (MRI) data of 70 male subjects, including 26 ASD (age range= 14-50 y, intelligence quotient [IQ]= 92-132), 16 AS (age range=7-58 y, IQ=93-133), and 28 HC (age range=9-39 y, IQ=95-144). Results of 1-way ANOVA on the GM density of 116 anatomically separated regions showed significant differences among the groups. The pattern of the structural covariance network indicated that covariation of GM density between the brain regions is altered in ASD. This altered structural covariance could be considered a reason for less efficient segregation and integration of information in the brain that could lead to cognitive dysfunctions in autism. We hope these findings could improve our understanding of the pathobiology of autism and may pave the way toward a more effective intervention paradigm. |
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| کلیدواژه‌های انگلیسی مقاله |
Autism spectrum disorder (ASD), Asperger syndrome (AS), Grey matter (GM) density, Magnetic resonance imaging (MRI), Structural covariance network (SCN) |
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| نویسندگان مقاله |
| Farnaz Faridi
Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
| Afrooz Seyedebrahimi
Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
| Reza Khosrowabadi
Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2262-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cognitive Neuroscience |
| نوع مقاله منتشر شده |
Original |
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