| چکیده انگلیسی مقاله |
Background: We earlier reported that datumetine possesses binding affinity with NMDAR and that 14-day exposure to datumetine altered NMDAR signalling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. Results: Relative to Veh, datumetine downregulate the expression of CamKIIα in the hippocampus and PFC but not in the cerebellum, CREB was also upregulated in the PFC only, but pCREB was also upregulated in all the three brain regions observed, while BDNF was only upregulated in both hippocampus and PFC of Datumetine relative to Veh. MK-801 on the other hand reversed some of the effects of datumetine in the brain regions observed. No major histological alterations were observed in the different brain regions immunohistochemically. Conclusion: We conclude that a single low dose of datumetine moderately enhances NMDAR activity. This showed the neuroprotective potentials of low datumetine exposure. |
| نویسندگان مقاله |
| Azeez Olakunle Ishola
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Adedeji Enitan Adetunji
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Isaac Chukwunwike Abanum
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Adesola Akorede Adeyemi
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Caleb Kenechukwu Faleye
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Jane Babale Martins
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Nnenna Chimdalu Ogbe
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Toluwalase Cherish Ogundipe
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Karen Ezichi Okewulonu
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Umo Emmanuel Okon
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Deborah Irenoise Ovbude
Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Richard Yomi Akele
Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti Nigeria.
| Naeemat Tolulope Omotade
Department of Anatomy, College of Health Technology Ijero-Ekiti, Nigeria.
| Moyosore Salihu Ajao
Department of Anatomy, University of Ilorin, Ilorin Nigeria.
|